Description

(6-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-2-Yl)-Acetic Acid is a high-purity fluorinated tetralin derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability for therapeutic applications. This compound is essential for R&D and production teams in the pharmaceutical and fine chemical industries, particularly those developing central nervous system (CNS) and cardiovascular active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting neurological and cardiovascular pathways.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and scale-up of new chemical entities (NCEs) where the fluorinated tetralin scaffold is required.
• Medicinal Chemistry Research: A versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Synthesis: Intermediate for producing specialized fluorinated compounds used in agrochemicals and material science.
• Reference Standard: Serves as an analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	(6-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-2-Yl)-Acetic Acid
CAS No.	885269-53-4
Molecular Formula	C₁₂H₁₃FO₂
Molecular Weight	208.23 g/mol
Synonyms	2-(6-Fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)acetic acid; 6-Fluoro-2-tetralylacetic acid; 2-(6-Fluorotetralin-2-yl)acetic Acid; (6-Fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)ethanoic acid; FTHAA; 885269-53-4; 6-Fluoro-2,3-dihydro-1H-indene-2-acetic acid (related structure); 6-Fluoro-tetralone-2-acetic acid derivative
EINECS	Contact for details

Quality Control

Our (6-Fluoro-1,2,3,4-Tetrahydro-Naphthalen-2-Yl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.