Description

4-(2,2,3,3-Tetrafluorocyclobutyl)-Bromobenzene is a high-value fluorinated aromatic building block, specifically a bromobenzene derivative with a tetrafluorocyclobutyl substituent. This compound is critical for introducing the unique steric and electronic properties of the tetrafluorocyclobutyl group into advanced molecular architectures. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for use in cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, to create novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Used to construct advanced scaffolds for new generation herbicides, fungicides, and insecticides with improved efficacy and environmental profile.
• Material Science: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with enhanced thermal stability and unique optical properties.
• Organic Synthesis: An essential reagent in Pd-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form biaryl and other complex structures.
• Fluorine Chemistry: Enables the study of structure-activity relationships (SAR) by incorporating the metabolically stable and lipophilic tetrafluorocyclobutyl moiety.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Item	Detail
Product Name	4-(2,2,3,3-Tetrafluorocyclobutyl)-Bromobenzene
CAS No.	885267-02-7
Molecular Formula	C10H7BrF4
Molecular Weight	283.06 g/mol
Synonyms	1-Bromo-4-(2,2,3,3-tetrafluorocyclobutyl)benzene; p-(2,2,3,3-Tetrafluorocyclobutyl)bromobenzene; 4-Bromo-1-(2,2,3,3-tetrafluorocyclobutyl)benzene; (4-Bromophenyl)(2,2,3,3-tetrafluorocyclobutane); Bromobenzene, 4-(2,2,3,3-tetrafluorocyclobutyl)-; Tetrafluorocyclobutyl Bromobenzene
EINECS	Contact for details

Quality Control

Every batch of 4-(2,2,3,3-Tetrafluorocyclobutyl)-Bromobenzene is manufactured under strict quality management systems. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥97.0% (Area %)
Purity (HPLC)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.