Description

Fmoc-D-Ala-Oh H2O CAS NO 884880-37-9 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This chiral building block is critical for introducing D-alanine residues into peptide chains, enabling the creation of complex, non-natural peptides with enhanced stability and biological activity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated, sequential construction of custom peptide sequences.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drugs, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Peptidomimetics & Bioconjugation: Serves as a key intermediate for creating peptide-like molecules (peptidomimetics) and for linking peptides to other molecules like dyes, polymers, or solid supports.
• Combinatorial Chemistry Libraries: Employed in generating diverse libraries of peptides for high-throughput screening against biological targets.
• Academic & Biochemical Research: Essential for studying protein-protein interactions, enzyme specificity, and structure-activity relationships (SAR) in model peptide systems.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of research-grade and GMP-grade peptides.

Basic Information

Product Name	Fmoc-D-Ala-Oh H2O
CAS No.	884880-37-9
Molecular Formula	C18H17NO5 • H2O
Molecular Weight	333.34 g/mol (monohydrate)
Synonyms	Fmoc-D-alanine; N-(9-Fluorenylmethoxycarbonyl)-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanoic acid; Fmoc-D-Ala-OH hydrate; Fmoc-D-Alanine-OH monohydrate; N-Fmoc-D-alanine; Fmoc-D-Ala; D-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrate (1:1)
EINECS	Contact for details

Quality Control

Our Fmoc-D-Ala-Oh H2O is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	4.0% - 6.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.