Description

tert-Butyl 3-(2,2,2-Trifluoroacetyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold protected by a Boc group and functionalized with a trifluoroacetyl moiety. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the trifluoroacetyl group, which can improve lipophilicity and binding affinity.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up the production of active pharmaceutical ingredients (APIs) under cGMP conditions.
• Agrochemical Synthesis: Employed in the research and development of novel pesticides and herbicides where the piperidine and fluorine-containing groups are beneficial.
• Chemical Biology Probes: Useful for creating labeled compounds or probes for studying biological mechanisms and enzyme interactions.
• Custom Synthesis & Contract Manufacturing: A requested compound for custom synthesis projects, supporting outsourcing needs in the fine chemical industry.

Basic Information

Product Name	tert-Butyl 3-(2,2,2-Trifluoroacetyl)Piperidine-1-Carboxylate
CAS No.	884512-51-0
Molecular Formula	C12H18F3NO3
Molecular Weight	281.27 g/mol
Synonyms	1-Boc-3-(2,2,2-Trifluoroacetyl)piperidine; 1-(tert-Butoxycarbonyl)-3-(trifluoroacetyl)piperidine; tert-Butyl 3-(trifluoroacetyl)piperidine-1-carboxylate; 3-Trifluoroacetyl-1-Boc-piperidine; 1-Boc-3-trifluoroacetylpiperidine; 3-(2,2,2-Trifluoroacetyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; Piperidine-1-carboxylic acid, 3-(2,2,2-trifluoroacetyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 3-(2,2,2-Trifluoroacetyl)Piperidine-1-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material that meets the specific standards required for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.