Description

3,3-Difluorocyclopentan-1-ol is a valuable fluorinated alcohol building block characterized by its cyclopentane ring structure. This compound matters for its role as a key chiral intermediate in the synthesis of complex, high-value molecules, particularly in the pharmaceutical sector. It is primarily needed by R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced material science applications where the introduction of fluorine atoms is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and metabolic disease therapeutics.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the difluorocyclopentyl moiety can enhance stability and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of fluorinated polymers and liquid crystals with unique electronic and surface properties.
• Chemical Biology Probes: Useful for synthesizing fluorinated analogs of natural products for mechanism-of-action studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production under cGMP guidelines.

Basic Information

Item	Detail
Product Name	3,3-Difluorocyclopentan-1-ol
CAS No.	883731-65-5
Molecular Formula	C5H8F2O
Molecular Weight	122.11 g/mol
Synonyms	3,3-Difluorocyclopentanol; 3,3-Difluoro-1-cyclopentanol; 1-Cyclopentanol, 3,3-difluoro-; 3,3-Difluorocyclopentyl alcohol; (3,3-Difluorocyclopentyl)methanol (isomer); 883731-65-5; 3,3-Difluoro-cyclopentan-1-ol
EINECS	Contact for details

Quality Control

Our 3,3-Difluorocyclopentan-1-ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality commitment supports compliance with ISO standards and the stringent requirements of cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage under an inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.