Description

4-(Trifluoromethyl)Cyclohexanemethanol (cis- And trans- Mixture) is a versatile fluorinated organic building block characterized by a cyclohexane ring substituted with a trifluoromethyl group and a hydroxymethyl moiety. This compound matters for its unique combination of lipophilicity, metabolic stability, and stereochemical diversity, making it a valuable intermediate in advanced synthesis. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by specialty chemical manufacturers for high-performance materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving performance and durability.
• Polymer Modification: Incorporated as a monomer or additive to impart specific properties like chemical resistance, low surface energy, or altered refractive index to specialty polymers and coatings.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and oxidation/reduction sequences to construct complex, fluorinated molecular architectures.
• Flavor & Fragrance Chemistry: Utilized in the synthesis of novel aroma chemicals and flavoring agents, leveraging the unique electronic properties of the CF3 group.

Basic Information

Product Name	4-(Trifluoromethyl)Cyclohexanemethanol (cis- And trans- Mixture)
CAS No.	883731-58-6
Molecular Formula	C8H13F3O
Molecular Weight	182.18 g/mol
Synonyms	4-(Trifluoromethyl)cyclohexylmethanol; (4-(Trifluoromethyl)cyclohexyl)methanol; Cyclohexanemethanol, 4-(trifluoromethyl)-, cis- and trans-; 4-(Trifluoromethyl)-1-cyclohexanemethanol; 4-(Trifluoromethyl)cyclohexane methanol; α-(Trifluoromethyl)cyclohexanemethanol; 4-CF3-Cyclohexanemethanol
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Cyclohexanemethanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with global regulatory frameworks, including REACH, and can tailor quality protocols to meet specific customer or pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. The product is moisture-sensitive; ensure containers are sealed tightly after use to prevent absorption of water vapor.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0% (Area %)
cis/trans Ratio (GC)	Reported on COA
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.