Description

2,3-Dimethyl-2-(Trimethylsilyloxy)Butanenitrile is a specialized organosilicon compound featuring a nitrile and a silyl-protected hydroxyl group. This unique structure makes it a valuable protected cyanohydrin synthon and a versatile intermediate in organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the construction of complex molecules, including active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral molecules and complex drug candidates.
• Fine Chemical Synthesis: Used in the preparation of specialty chemicals, agrochemicals, and advanced materials.
• Cyanohydrin Chemistry: Serves as a protected cyanohydrin equivalent in nucleophilic addition reactions.
• Silicon-Mediated Transformations: Utilized in reactions where the trimethylsilyloxy group acts as a leaving group or protecting group.
• Asymmetric Synthesis: Potential precursor for chiral auxiliaries or ligands in catalytic processes.
• Research & Development: Valuable reagent for method development and exploring new synthetic pathways in academic and industrial labs.

Basic Information

Product Name	2,3-Dimethyl-2-(Trimethylsilyloxy)Butanenitrile
CAS No.	883726-88-3
Molecular Formula	C9H19NOSi
Molecular Weight	185.34 g/mol
Synonyms	2,3-Dimethyl-2-((trimethylsilyl)oxy)butanenitrile; 2-(Trimethylsilyloxy)-2,3-dimethylbutyronitrile; Butanenitrile, 2,3-dimethyl-2-[(trimethylsilyl)oxy]-; TMS-protected 2,3-dimethyl-2-hydroxybutyronitrile; Trimethylsilyl 2-cyano-2,3-dimethyl-2-butoxide
EINECS	Contact for details

Quality Control

Every batch of 2,3-Dimethyl-2-(Trimethylsilyloxy)Butanenitrile is produced and tested under strict quality management protocols. We ensure high purity and batch-to-batch consistency through comprehensive analytical characterization, including NMR, GC, and HPLC analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles to meet your specific R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.