Description

2-Fluoro-5-Trifluoromethylbenzyl Chloride is a high-value, multi-functional aromatic building block characterized by its reactive benzyl chloride group and electron-withdrawing fluorine substituents. This compound is essential for introducing the 2-fluoro-5-trifluoromethylbenzyl moiety into complex molecular architectures, enabling precise tuning of physical and chemical properties. It is primarily sought after by R&D and production chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active ingredients, and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in constructing novel herbicides, fungicides, and insecticides where the trifluoromethyl and fluorine groups enhance bioactivity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to incorporate fluorinated benzyl groups into specialty polymers, enhancing chemical resistance, surface properties, and durability.
• Cross-Coupling Reactions: A versatile substrate for palladium-catalyzed reactions (e.g., Suzuki, Heck) to create complex, fluorinated biaryl structures.
• Organic Synthesis Building Block: Fundamental reagent for nucleophilic substitution reactions, facilitating the introduction of various functional groups via the reactive chlorine atom.

Basic Information

Product Name	2-Fluoro-5-Trifluoromethylbenzyl Chloride
CAS No.	883543-26-8
Molecular Formula	C8H5ClF4
Molecular Weight	212.57 g/mol
Synonyms	1-(Chloromethyl)-2-fluoro-5-(trifluoromethyl)benzene; α-Chloro-2-fluoro-α,α,α-trifluoro-p-xylene; 2-Fluoro-α,α,α-trifluoro-p-tolyl chloride; (2-Fluoro-5-trifluoromethylphenyl)methyl chloride; 5-(Chloromethyl)-2-fluorobenzotrifluoride; 2-Fluoro-5-trifluoromethylbenzylchloride; Benzene, 1-(chloromethyl)-2-fluoro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Trifluoromethylbenzyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent hydrolysis. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.