Description

2-{[4-(Trifluoromethyl)Phenoxy]Methyl}Pyrrolidine is a high-value, fluorinated pyrrolidine derivative with a distinct trifluoromethylphenoxy moiety. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or catalysts in asymmetric synthesis, leveraging the pyrrolidine nitrogen for metal coordination.
• Material Science: Incorporated into specialty polymers or liquid crystals to modify thermal stability, solubility, and electronic properties.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular scaffold in probe discovery.

Basic Information

Product Name	2-{[4-(Trifluoromethyl)Phenoxy]Methyl}Pyrrolidine
CAS No.	883542-65-2
Molecular Formula	C12H14F3NO
Molecular Weight	245.24 g/mol
Synonyms	2-[(4-Trifluoromethylphenoxy)methyl]pyrrolidine; 2-[[4-(Trifluoromethyl)phenoxy]methyl]pyrrolidine; Pyrrolidine, 2-[[[4-(trifluoromethyl)phenyl]oxy]methyl]-; 2-({[4-(Trifluoromethyl)phenyl]oxy}methyl)pyrrolidine; 2-(4-Trifluoromethylphenoxymethyl)pyrrolidine; 2-((4-Trifluoromethylphenoxy)methyl)pyrrolidine; 2-[[(4-Trifluoromethylphenyl)oxy]methyl]pyrrolidine
EINECS	Contact for details

Quality Control

Every batch of 2-{[4-(Trifluoromethyl)Phenoxy]Methyl}Pyrrolidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.