Description

(-)-n-[(4-Methylphenyl)Sulfonyl]-D-Glutamine is a high-purity, chiral sulfonamide derivative of D-glutamine, designed for advanced research and synthesis. This compound is valued for its role as a specialized building block in the development of novel pharmaceutical agents and biochemical probes. It is primarily utilized by researchers and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for applications requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Protease Inhibitor Research: Serves as a potential scaffold or precursor in the design of enzyme inhibitors, leveraging the glutamine and sulfonamide moieties.
• Bioconjugation & Probe Development: Used in the synthesis of labeled compounds or affinity probes for studying biological pathways and protein interactions.
• Peptidomimetic Chemistry: Acts as a constrained amino acid analog in the creation of peptidomimetics to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in stereoselective synthetic routes to access enantiomerically pure compounds.

Basic Information

Product Name	(-)-n-[(4-Methylphenyl)Sulfonyl]-D-Glutamine
CAS No.	883452-10-6
Molecular Formula	C12H16N2O5S
Molecular Weight	300.33 g/mol
Synonyms	D-Glutamine, N-[(4-methylphenyl)sulfonyl]-; N-Tosyl-D-glutamine; (-)-N-(p-Toluenesulfonyl)-D-glutamine; (2R)-2-Amino-4-carbamoyl-1-oxobutyl 4-methylbenzenesulfonate; p-Toluenesulfonyl-D-glutamine; (R)-2-((4-Methylphenyl)sulfonamido)-4-carbamoylbutanoic acid; TSG; Tosyl-D-glutamine
EINECS	Contact for details

Quality Control

Our (-)-n-[(4-Methylphenyl)Sulfonyl]-D-Glutamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.