Description

2-(Acetylamino)-3-(3,5-Difluorophenyl)-2-Propenoicacid is a high-purity, fluorinated organic building block of significant interest in advanced pharmaceutical synthesis. This compound matters because its unique difluorophenyl and propenoic acid structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. Pharmaceutical R&D teams and fine chemical manufacturers need this material for constructing complex molecules where the introduction of fluorine atoms is essential for modulating bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the difluorophenyl moiety can enhance biological activity and environmental stability.
• Fluorinated Compound Library Synthesis: Serves as a versatile scaffold for creating diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and advanced materials that benefit from fluorine's unique properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	2-(Acetylamino)-3-(3,5-Difluorophenyl)-2-Propenoicacid
CAS No.	883035-24-3
Molecular Formula	C11H9F2NO3
Molecular Weight	241.19 g/mol
Synonyms	2-Acetamido-3-(3,5-difluorophenyl)acrylic acid; (2E)-2-Acetamido-3-(3,5-difluorophenyl)prop-2-enoic acid; 3-(3,5-Difluorophenyl)-2-(acetylamino)-2-propenoic acid; α-Acetamido-3,5-difluorocinnamic acid; NSC 796373; 2-Propenoic acid, 2-(acetylamino)-3-(3,5-difluorophenyl)-; AKOS005258160
EINECS	Contact for details

Quality Control

Our 2-(Acetylamino)-3-(3,5-Difluorophenyl)-2-Propenoicacid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.