Description

Fmoc-n-[2-(Tritylmercapto)Ethyl]-Glycine CAS NO 882847-27-0 is a specialized, high-purity amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is engineered to provide superior protection for the thiol group during complex peptide assembly, ensuring high coupling efficiency and minimal side reactions. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the controlled introduction of cysteine or cysteine-like residues into peptide chains.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates, useful in targeted drug delivery systems.
• Chemical Biology: Employed in the synthesis of peptide probes and tools for studying protein-protein interactions and enzyme mechanisms.
• Material Science: Can be utilized to create peptide-functionalized surfaces or biomaterials with specific chemical properties.

Basic Information

Product Name	Fmoc-n-[2-(Tritylmercapto)Ethyl]-Glycine
CAS No.	882847-27-0
Molecular Formula	C40H35NO4S
Molecular Weight	625.78 g/mol
Synonyms	Fmoc-N-[2-(Tritylthio)ethyl]glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-[2-(triphenylmethylthio)ethyl]glycine; Fmoc-Cys(Trt)-OH analog; Fmoc-S-tritylcysteamine-glycine; Fmoc-N-(2-((Triphenylmethyl)thio)ethyl)glycine; N-Fmoc-N-(2-(tritylthio)ethyl)glycine; Protected Cysteamine-Glycine Derivative
EINECS	Contact for details

Quality Control

Our Fmoc-n-[2-(Tritylmercapto)Ethyl]-Glycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis where applicable, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.