Description

Boc-21-Amino-4,7,10,13,16,19-Hexaoxaheneicosanoic Acid is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a Boc-protected amine and a carboxylic acid group. This compound is specifically engineered for the controlled conjugation and functionalization of biomolecules, offering a hydrophilic spacer to enhance solubility and reduce immunogenicity. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science, particularly for creating peptide-drug conjugates, diagnostic probes, and hydrogel networks.

Application

• Bioconjugation Linker: Serves as a heterobifunctional crosslinker for coupling peptides, proteins, or antibodies to drugs, surfaces, or other molecules.
• PEGylation Reagent: Used to introduce a hydrophilic PEG spacer onto bioactive molecules to improve pharmacokinetic properties, such as increased circulation half-life and reduced aggregation.
• Peptide Synthesis Intermediate: A key protected intermediate in solid-phase and solution-phase peptide synthesis for incorporating PEGylated amino acid segments.
• Diagnostic Probe Development: Facilitates the creation of labeled probes for imaging and diagnostic assays by linking targeting moieties to reporter molecules.
• Hydrogel and Biomaterial Fabrication: Acts as a functional monomer or crosslinking agent in the synthesis of biocompatible hydrogels for drug delivery and tissue engineering.
• Surface Functionalization: Used to modify nanoparticles, chips, or other material surfaces with amine-reactive groups for subsequent biomolecule immobilization.
• ADC (Antibody-Drug Conjugate) Payload Attachment: Enables the site-specific attachment of cytotoxic payloads to antibodies via a cleavable or non-cleavable linker system.

Basic Information

Product Name	Boc-21-Amino-4,7,10,13,16,19-Hexaoxaheneicosanoic Acid
CAS No.	882847-13-4
Molecular Formula	C23H45NO10
Molecular Weight	495.61 g/mol
Synonyms	Boc-NH-PEG6-COOH; Boc-Amino-PEG6-Acid; 21-[(2-Methyl-2-propanoxy)carbonyl]amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid; tert-Butyl (19-carboxy-4,7,10,13,16-pentaoxanonadecyl)carbamate; Boc-15-amino-4,7,10,13-tetraoxapentadecanoic acid (common naming variant); Boc-PEG6-acid; Heterobifunctional PEG, Boc-amine, acid; Boc-N-amido-PEG6-acid
EINECS	Contact for details

Quality Control

Every batch of Boc-21-Amino-4,7,10,13,16,19-Hexaoxaheneicosanoic Acid is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and pre-clinical development. Comprehensive Certificates of Analysis (COA) detailing purity by HPLC, NMR confirmation, and other critical parameters are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.