Description

3-Fluoro-4-Methylene-1-Piperidinecarboxylic Acid tert-Butyl Ester is a high-value, fluorinated piperidine derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its unique structural features, combining a reactive exocyclic methylene group with a fluorine atom and a Boc-protected amine, enabling precise molecular modifications. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex nitrogen-containing heterocycles in drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science Research: Potential monomer or precursor for specialty polymers and advanced materials with tailored properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in fluorination chemistry and heterocyclic chemistry.

Basic Information

Product Name	3-Fluoro-4-Methylene-1-Piperidinecarboxylic Acid tert-Butyl Ester
CAS No.	882033-92-3
Molecular Formula	C12H20FNO2
Molecular Weight	229.29 g/mol
Synonyms	tert-Butyl 3-fluoro-4-methylenepiperidine-1-carboxylate; 1-Boc-3-fluoro-4-methylenepiperidine; 1-(tert-Butoxycarbonyl)-3-fluoro-4-methylenepiperidine; 3-Fluoro-4-methylenepiperidine-1-carboxylic acid tert-butyl ester; 882033-92-3; 3-Fluoro-4-methylene-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 4-Methylene-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methylene-1-Piperidinecarboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.