Description

Fmoc-2-Me-Nval-Oh CAS NO 881921-10-4 is a high-purity, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of sterically hindered, branched-chain amino acid analogs into complex peptide sequences. It is essential for research and development in pharmaceutical discovery, enabling the creation of novel peptide-based therapeutics with enhanced metabolic stability and binding affinity. Target users include peptide chemists, process development scientists, and manufacturers in the biotechnology and pharmaceutical industries.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical R&D: For the development of novel peptide drugs, hormones, and diagnostic agents incorporating modified amino acid structures.
• Peptidomimetic Design: To introduce steric bulk and conformational constraints into peptide backbones, improving pharmacological properties.
• Bioconjugation: As a specialized linker or intermediate for attaching peptides to other molecules, surfaces, or carriers.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic Research: A vital reagent for studying protein structure-function relationships and enzyme-substrate interactions.

Basic Information

Product Name	Fmoc-2-Me-Nval-Oh
CAS No.	881921-10-4
Molecular Formula	C₂₂H₂₅NO₄
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-2-methylnorvaline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methyl-L-norvaline; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methylpentanoic acid; Fmoc-2-Me-Nva-OH; Fmoc-2-methyl-Nva-OH; Fmoc-2-methylnorvaline-OH; Fmoc-(2-Me)Nva-OH; N-α-Fmoc-2-methylnorvaline
EINECS	Contact for details

Quality Control

Our Fmoc-2-Me-Nval-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, chiral analysis to confirm enantiomeric integrity, and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.