Description

(R)-Fmoc-α-Methyl-Phenylglycine is a non-natural, chiral amino acid derivative specifically engineered for advanced peptide synthesis. This compound matters as a critical building block for introducing sterically hindered, optically pure phenylglycine analogs into peptide chains, enabling the development of novel pharmaceuticals and bioactive molecules with enhanced stability and specificity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostic agents, and complex organic molecules where precise stereochemistry is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, facilitating the incorporation of (R)-α-methyl-phenylglycine residues.
• Pharmaceutical Intermediate: Serves as a crucial chiral precursor in the synthesis of peptidomimetics and active pharmaceutical ingredients (APIs) with modified backbone structures.
• Proteomics & Biochemical Research: Used to create custom peptides with enhanced resistance to enzymatic degradation for structure-activity relationship (SAR) studies.
• Ligand Development: Employed in the synthesis of chiral ligands for asymmetric catalysis and molecular recognition applications.
• Material Science: Can be utilized to create functionalized, chiral organic frameworks and polymers with specific stereochemical properties.

Basic Information

Product Name	(R)-Fmoc-α-Methyl-Phenylglycine
CAS No.	881920-86-1
Molecular Formula	C25H23NO4
Molecular Weight	401.46 g/mol
Synonyms	Fmoc-(R)-α-Me-Phg-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methyl-2-phenylacetic acid; (R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methylphenylglycine; (R)-Fmoc-α-methyl-2-phenylglycine; Fmoc-(R)-α-methylphenylglycine; (R)-Fmoc-Ampg-OH; N-α-Fmoc-(R)-α-methylphenylglycine; (R)-2-(Fmoc-amino)-2-methyl-2-phenylacetic acid
EINECS	Contact for details

Quality Control

Our (R)-Fmoc-α-Methyl-Phenylglycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard spectroscopic methods for identity confirmation, to ensure compliance with high-purity research-grade standards. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request to support your critical R&D and cGMP development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.