Description

(E)-Ethyl 3-(2,5-Difluorophenyl)Acrylate (Wx618079) is a high-purity fluorinated acrylate ester building block, essential for advanced organic synthesis. Its core value lies in the strategic placement of fluorine atoms on the phenyl ring, which significantly influences the electronic properties, metabolic stability, and lipophilicity of target molecules. This compound is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing potential drug candidates, especially in kinase inhibitor and anti-inflammatory research, where the difluorophenyl moiety is a privileged structure.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging fluorine's ability to enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and coatings with tailored surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: Acts as a fluorinated component in the synthesis of electronic materials for displays and lighting, where fluorine atoms improve charge transport and stability.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new reactions, such as cross-coupling or cycloaddition, involving fluorinated acrylates.
• Fluorine Chemistry Library Building: Essential for creating focused chemical libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	(E)-Ethyl 3-(2,5-Difluorophenyl)Acrylate (Wx618079)
CAS No.	881658-90-8
Molecular Formula	C11H10F2O2
Molecular Weight	212.19 g/mol
Synonyms	Ethyl (E)-3-(2,5-Difluorophenyl)propenoate; (E)-Ethyl 3-(2,5-Difluorophenyl)-2-propenoate; 2-Propenoic acid, 3-(2,5-difluorophenyl)-, ethyl ester, (E)-; Ethyl (E)-3-(2,5-Difluorophenyl)acrylate; WX-618079; Wx618079; 2,5-Difluorocinnamic acid ethyl ester (E-isomer)
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 3-(2,5-Difluorophenyl)Acrylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity, isomeric purity (E-isomer), and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E-isomer, HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.