Description

(R)-3-Amino-4,4,4-Trifluorobutan-1-Ol CAS NO 881539-56-6 is a high-value, chiral fluorinated building block essential for modern pharmaceutical and agrochemical synthesis. Its unique structure, featuring both an amino and a hydroxyl group on a trifluoromethyl-substituted carbon chain, makes it a critical intermediate for introducing chirality and fluorine atoms into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas like enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), especially in protease inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, improving enantioselectivity in critical bond-forming reactions.
• Peptidomimetics Research: Incorporated into peptide analogs to modulate bioavailability, metabolic stability, and binding affinity for drug discovery programs.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine substitution on molecular conformation and reactivity in academic and industrial R&D settings.
• Material Science Precursor: Potential use in synthesizing specialized fluorinated polymers or surface-modifying agents with unique properties.

Basic Information

Product Name	(R)-3-Amino-4,4,4-Trifluorobutan-1-Ol
CAS No.	881539-56-6
Molecular Formula	C4H8F3NO
Molecular Weight	143.11 g/mol
Synonyms	(R)-3-Amino-4,4,4-trifluorobutan-1-ol; (3R)-3-Amino-4,4,4-trifluorobutanol; (R)-4,4,4-Trifluoro-3-aminobutan-1-ol; (R)-3-Amino-1,1,1-trifluorobutan-4-ol; (R)-3-Amino-4,4,4-trifluorobutyl alcohol; (R)-3-Amino-1,1,1-trifluoro-4-hydroxybutane; (R)-γ-Amino-γ,γ,γ-trifluorobutanol; 881539-56-6
EINECS	Contact for details

Quality Control

Our (R)-3-Amino-4,4,4-Trifluorobutan-1-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (HPLC/Chiral HPLC), and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.