Description

4,4,5,5-Tetramethyl-2-(2,3,4-Trifluorophenyl)-1,3,2-Dioxaborolane is a high-purity, trifluorinated aryl boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its exceptional utility as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality organoboron reagents for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing trifluoromethylated or fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the introduction of the 2,3,4-trifluorophenyl moiety is desired.
• Material Science: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands and catalysts for asymmetric synthesis and other transition metal-catalyzed processes.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new synthetic methodologies and complex molecule construction.
• Fluorinated Compound Library Synthesis: Critical for generating diverse libraries of fluorinated compounds for high-throughput screening in drug discovery programs.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(2,3,4-Trifluorophenyl)-1,3,2-Dioxaborolane
CAS No.	881401-96-3
Molecular Formula	C12H13BF3O2
Molecular Weight	248.04 g/mol
Synonyms	2-(2,3,4-Trifluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2,3,4-Trifluorophenyl)boronic acid pinacol ester; 2,3,4-Trifluorophenylboronic acid pinacol ester; Pinacol (2,3,4-Trifluorophenyl)boronate; 4,4,5,5-Tetramethyl-2-(2,3,4-trifluorophenyl)-1,3,2-dioxaborolane; 2,3,4-Trifluorophenyl-Bpin; 881401-96-3
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(2,3,4-Trifluorophenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 19F, 11B) and HPLC analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (argon or nitrogen) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.