Description

3-(5-Bromo-2-Fluorophenyl)Propionic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromo and fluoro substituents on the phenyl ring, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting new small molecule entities.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for fluorinated aromatic cores used in electronic materials and display technologies.
• Cross-Coupling Reactions: The bromo substituent acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, or Stille couplings to create biaryl structures.
• Fine Chemical Synthesis: Intermediate for producing specialized fluorinated compounds used in dyes, pigments, and advanced polymers.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	3-(5-Bromo-2-Fluorophenyl)Propionic Acid
CAS No.	881189-58-8
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	5-Bromo-2-fluorobenzene propanoic acid; 3-(5-Bromo-2-fluorophenyl)propanoic acid; 5-Bromo-2-fluorohydrocinnamic acid; (5-Bromo-2-fluorophenyl)propionic acid; 881189-58-8; 3-(5-Bromo-2-fluorophenyl)propionic acid; 2-Fluoro-5-bromohydrocinnamic acid; β-(5-Bromo-2-fluorophenyl)propionic acid
EINECS	Contact for details

Quality Control

Our 3-(5-Bromo-2-Fluorophenyl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements of research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom purity grades are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 98.0% / ≥ 99.0% (High Purity Grades)
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.