Description

Norleucine, n-Chloroacetyl-2-Isopropyl- (5Ci) is a specialized, high-purity synthetic amino acid derivative designed for advanced research and pharmaceutical development. This compound serves as a critical chiral building block and intermediate in the synthesis of complex bioactive molecules, offering precise structural control. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications such as peptide mimetics and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including protease inhibitors and receptor antagonists.
• Peptidomimetics Synthesis: Used to construct non-natural amino acid residues that enhance the metabolic stability and bioavailability of peptide-based drugs.
• Chemical Biology Research: Employed as a molecular probe or building block in studying protein-protein interactions and enzyme mechanisms.
• Process Chemistry: Serves as a critical intermediate in the scalable, GMP-compliant manufacturing routes for complex Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the 2-isopropyl-norleucine moiety into target molecules.

Basic Information

Product Name	Norleucine, n-Chloroacetyl-2-Isopropyl- (5Ci)
CAS No.	880765-84-4
Molecular Formula	C11H20ClNO3
Molecular Weight	249.73 g/mol
Synonyms	N-Chloroacetyl-2-isopropylnorleucine; 2-Isopropyl-N-(chloroacetyl)norleucine; (2S)-2-Amino-6-methyl-2-[(1-methylethyl)amino]-N-(chloroacetyl)hexanamide; 2-Isopropylnorleucine N-chloroacetyl derivative; Norleucine, N-chloroacetyl-2-isopropyl-; 5Ci-labeled Norleucine derivative; Chloroacetyl-isopropyl-norleucine
EINECS	Contact for details

Quality Control

Every batch of Norleucine, n-Chloroacetyl-2-Isopropyl- (5Ci) is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide full traceability and Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles by techniques such as HPLC, NMR, and MS. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.