Description

3-Bromo-n-Methoxy-n-Methyl-5-(Trifluoromethyl)Benzamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and trifluoromethylated aromatic structure. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions due to its halogen handle for further derivatization.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	3-Bromo-n-Methoxy-n-Methyl-5-(Trifluoromethyl)Benzamide
CAS No.	880652-44-8
Molecular Formula	C11H11BrF3NO2
Molecular Weight	326.11 g/mol
Synonyms	3-Bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide; 5-(Trifluoromethyl)-3-bromo-N-methoxy-N-methylbenzamide; Benzamide, 3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)-; N-Methoxy-N-methyl-3-bromo-5-trifluoromethylbenzamide; 3-Bromo-N-methoxy-N-methyl-5-trifluoromethylbenzamide; 880652-44-8; Amide coupling reagent derivative; Weinreb amide derivative
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-n-Methoxy-n-Methyl-5-(Trifluoromethyl)Benzamide is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.