Description

Tanezumab is a humanized monoclonal antibody designed to selectively target and inhibit nerve growth factor (NGF). This targeted mechanism of action makes it a significant investigational therapeutic agent for the management of chronic pain conditions. It is primarily utilized in pharmaceutical research and development for its potential in treating osteoarthritis and chronic lower back pain. Tanezumab CAS NO 880266-57-9 represents a promising non-opioid approach to pain relief, attracting interest from biopharmaceutical companies and clinical research organizations globally.

Application

• Pharmaceutical R&D: Investigational therapeutic agent for chronic pain conditions, including osteoarthritis and chronic lower back pain.
• Biologics Manufacturing: Serves as a reference standard or active pharmaceutical ingredient (API) in the production of biologic drug candidates.
• Preclinical & Clinical Studies: Used in pharmacokinetic, pharmacodynamic, and safety-efficacy studies during drug development phases.
• Mechanism of Action Research: Critical tool for studying the role of Nerve Growth Factor (NGF) in pain signaling pathways.
• Analytical Method Development: Employed as a standard in developing and validating bioanalytical assays (e.g., ELISA, LC-MS).
• Formulation Development: Used in stability studies and the development of parenteral formulations for biologic drugs.

Basic Information

Product Name	Tanezumab
CAS No.	880266-57-9
Molecular Formula	Contact for details
Molecular Weight	Approx. 150 kDa (Contact for details)
Synonyms	RN624; PF-04383119; Anti-NGF Monoclonal Antibody; Tanezumab (USAN); Humanized anti-NGF Antibody; Nerve Growth Factor Inhibitor; Monoclonal Antibody RN624
EINECS	Contact for details

Quality Control

Our Tanezumab is manufactured and controlled under stringent quality systems suitable for research and development applications. Each batch is subjected to a comprehensive panel of analytical tests to ensure identity, purity, potency, and consistency. Certificates of Analysis (COA) are provided, detailing specifications for critical quality attributes such as purity by SEC-HPLC, endotoxin levels, and biological activity. We support compliance with relevant guidelines for investigational products.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product should be handled under aseptic conditions to maintain sterility where applicable.

Specification

Item	Specification
Appearance	Clear to slightly opalescent, colorless to pale yellow solution
Identification (SEC-HPLC / MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Concentration	As per COA (Typically 1-10 mg/mL)
Potency (Cell-based Assay)	Contact for details
Endotoxin	< 1.0 EU/mg
pH	6.0 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.