Description

N,N'-(1S)-[1,1'-Binaphthalene]-2,2'-Diylbis[2-(Diphenylphosphino)-Benzamide is a sophisticated chiral ligand belonging to the BINAP (2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl) family, specifically functionalized with benzamide groups. This compound matters for its ability to impart high enantioselectivity in transition metal-catalyzed asymmetric synthesis, a critical factor in producing single-enantiomer pharmaceuticals and fine chemicals. Industrial researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical sectors need this ligand to develop efficient and selective catalytic processes for complex molecule construction.

Application

• Asymmetric Hydrogenation: A key ligand for rhodium or ruthenium-catalyzed enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Enables the production of chiral active pharmaceutical ingredients (APIs) with high optical purity.
• Cross-Coupling Reactions: Can be utilized in palladium-catalyzed asymmetric cross-coupling reactions for C-C and C-X bond formation.
• Asymmetric Isomerization: Applied in metal-catalyzed enantioselective isomerization reactions.
• Catalyst Screening Libraries: Serves as a valuable component in high-throughput screening for discovering new asymmetric transformations.
• Academic & Process R&D: Used in research laboratories for developing novel catalytic methodologies and optimizing synthetic routes.

Basic Information

Item	Details
Product Name	N,N'-(1S)-[1,1'-Binaphthalene]-2,2'-Diylbis[2-(Diphenylphosphino)-Benzamide
CAS No.	879505-38-1
Molecular Formula	C66H48N2O2P2
Molecular Weight	963.03 g/mol
Synonyms	(S)-BINAM-BINAP; (S)-2,2'-Bis[N-(2-diphenylphosphinobenzoyl)amino]-1,1'-binaphthyl; (S)-N,N'-[1,1'-Binaphthalene]-2,2'-diylbis[2-(diphenylphosphino)benzamide]; (S)-BINAP-amide derivative; BINAP-based P,N-ligand; Chiral diphosphine ligand; Axially chiral bisphosphine ligand
EINECS	Contact for details

Quality Control

Our production of N,N'-(1S)-[1,1'-Binaphthalene]-2,2'-Diylbis[2-(Diphenylphosphino)-Benzamide adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and elemental analysis to confirm identity, chiral purity (enantiomeric excess), and chemical assay. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (argon or nitrogen) is recommended. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to light brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.