Description

2-Difluoromethyl-Phenylboronic Acid is a high-purity organoboron reagent featuring a difluoromethyl substituent, which is critical for modulating the electronic and steric properties of target molecules. This compound is essential for modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the efficient construction of complex fluorinated biaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides with enhanced metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for creating fluorinated organic electronic materials, such as OLED and OFET components.
• Suzuki-Miyaura Cross-Coupling: A versatile reagent for palladium-catalyzed carbon-carbon bond formation to create complex, fluorinated biaryl scaffolds.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes for studying biological processes and protein interactions.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel fluorinated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Difluoromethyl-Phenylboronic Acid
CAS No.	879275-70-4
Molecular Formula	C7H7BF2O2
Molecular Weight	171.94 g/mol
Synonyms	[2-(Difluoromethyl)phenyl]boronic Acid; (2-Difluoromethylphenyl)boronic Acid; 2-(Difluoromethyl)benzeneboronic Acid; Boronic acid, B-[2-(difluoromethyl)phenyl]-; 879275-70-4; 2-Difluoromethylbenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Difluoromethyl-Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.