Description

2-Fluoro-2-Methyl-Propylamine Hydrochloride is a high-purity, organofluorine building block essential for advanced chemical synthesis. This compound matters for its role in introducing a sterically hindered, fluorine-containing amine moiety, which is critical for modulating the physicochemical and metabolic properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the fluorine atom and amine group can enhance biological activity and environmental stability.
• Peptide Modification: Serves as a specialty reagent for the site-specific incorporation of fluorinated amino acid analogs into peptides and proteins to study structure-activity relationships.
• Ligand Synthesis for Catalysis: Employed in the preparation of fluorinated ligands for transition metal catalysts, potentially improving catalytic efficiency and selectivity in asymmetric synthesis.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Fluorine-18 Radiochemistry: May serve as a precursor or reference standard in the development of Positron Emission Tomography (PET) tracers for diagnostic imaging.

Basic Information

Item	Details
Product Name	2-Fluoro-2-Methyl-Propylamine Hydrochloride
CAS No.	879001-63-5
Molecular Formula	C4H11ClFN
Molecular Weight	127.59 g/mol
Synonyms	2-Fluoro-2-methylpropylamine hydrochloride; 1-Amino-2-fluoro-2-methylpropane hydrochloride; (2-Fluoro-2-methylpropyl)amine hydrochloride; 2-Fluoro-2-methyl-1-propanamine hydrochloride; tert-Butylfluoromethylamine hydrochloride; 2-Fluoro-tert-butylamine hydrochloride; 2-Fluoro-2-methylpropane-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Fluoro-2-Methyl-Propylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.