Description

tert-Butyl 4-Hydroxy-4-Methylazepane-1-Carboxylate is a high-purity, protected azepane derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile chiral intermediate, enabling the construction of complex nitrogen-containing heterocycles with precise stereochemistry. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, as well as by fine chemical manufacturers producing custom intermediates for clients in these sectors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and pesticides that require specific stereochemical configurations for optimal activity.
• Fine Chemical Manufacturing: Serves as a versatile building block for custom synthesis and contract manufacturing of complex, high-value specialty chemicals.
• Academic & Industrial Research: Employed in medicinal chemistry programs and process chemistry development for method optimization and scale-up studies.
• Ligand and Catalyst Development: Useful precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	tert-Butyl 4-Hydroxy-4-Methylazepane-1-Carboxylate
CAS No.	878631-04-0
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	1-Boc-4-Hydroxy-4-methylazepane; 4-Methyl-4-hydroxyazepane-1-carboxylic acid tert-butyl ester; tert-Butyl 4-hydroxy-4-methyl-1-azepanecarboxylate; 1-(tert-Butoxycarbonyl)-4-hydroxy-4-methylazepane; 4-Hydroxy-4-methylazepane-1-carboxylic acid tert-butyl ester; Azepane-1-carboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester; 1-N-Boc-4-hydroxy-4-methylazepane
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Hydroxy-4-Methylazepane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.