Description

(S)-3-(4'-Bromophenyl)-3-Hydroxypropanenitrile is a high-value chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its core value lies in the presence of both a nitrile and a hydroxyl group on a stereogenic center, enabling its use in the construction of complex, optically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Research: Used in the development of novel, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Synthesis: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex natural products, flavors, and fragrances requiring high stereochemical purity.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, including new asymmetric transformation development.

Basic Information

Product Name	(S)-3-(4'-Bromophenyl)-3-Hydroxypropanenitrile
CAS No.	877876-70-5
Molecular Formula	C9H8BrNO
Molecular Weight	226.07 g/mol
Synonyms	(S)-3-Hydroxy-3-(4-bromophenyl)propanenitrile; (S)-3-(4-Bromophenyl)-3-hydroxypropionitrile; (S)-γ-Hydroxy-4-bromobenzene propanenitrile; (S)-4'-Bromo-β-hydroxybenzenepropanenitrile; (S)-3-(p-Bromophenyl)-3-hydroxypropionitrile; (S)-3-(4-Bromophenyl)-3-hydroxypropanenitrile; (S)-3-Hydroxy-3-(p-bromophenyl)propionitrile; (S)-3-(4-Bromophenyl)-3-hydroxy-2-propenenitrile (tautomer)
EINECS	Contact for details

Quality Control

Our (S)-3-(4'-Bromophenyl)-3-Hydroxypropanenitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR, and IR for structural confirmation. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.