Description

4-Methylthio-3-(trifluoromethyl)phenylboronic acid is a specialized organoboron compound that serves as a crucial building block in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecules through efficient cross-coupling reactions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and advanced materials.

Application

This boronic acid derivative is a versatile reagent with applications across advanced chemical synthesis.

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing trifluoromethyl and arylthioether motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs, due to its unique electronic properties imparted by the sulfur and fluorine atoms.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful in constructing molecular probes for studying biological processes and enzyme inhibition.

Basic Information

Item	Details
Product Name	4-Methylthio-3-(Trifluoromethyl)Phenylboronic Acid
CAS No.	877383-11-4
Molecular Formula	C8H8BF3O2S
Molecular Weight	235.02 g/mol
Synonyms	[4-(Methylthio)-3-(trifluoromethyl)phenyl]boronic acid; 3-Trifluoromethyl-4-methylthiophenylboronic acid; 4-Methylsulfanyl-3-trifluoromethylbenzeneboronic acid; (4-Methylthio-3-trifluoromethylphenyl)boronic acid; Boronic acid, B-[4-(methylthio)-3-(trifluoromethyl)phenyl]-; 877383-11-4
EINECS	Contact for details

Quality Control

Our production of 4-Methylthio-3-(trifluoromethyl)phenylboronic acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.