Description

4-Bromo-2-Trifluoromethylphenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. Its molecular structure, featuring both bromine and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules in advanced chemical synthesis. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and liquid crystals, due to its electron-withdrawing properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated aromatic scaffolds.

Basic Information

Product Name	4-Bromo-2-Trifluoromethylphenylacetonitrile
CAS No.	877131-92-5
Molecular Formula	C9H5BrF3N
Molecular Weight	264.04 g/mol
Synonyms	2-(4-Bromo-2-(trifluoromethyl)phenyl)acetonitrile; (4-Bromo-2-(trifluoromethyl)phenyl)acetonitrile; 4-Bromo-α-(trifluoromethyl)benzeneacetonitrile; 2-(4-Bromo-2-trifluoromethylphenyl)acetonitrile; 4-Bromo-2-trifluoromethylbenzyl cyanide; α-(4-Bromo-2-trifluoromethylphenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Trifluoromethylphenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.