Description

(Ar,Ar)-2,2'-Bis(A-N,n-Dimethylaminophenylmethyl)-(S,S)-1,1'-Bis[Di-(3,5-Dimethyl-4-Methoxyphenyl)-Phosphino]-Ferrocene is a highly specialized, chiral ferrocenyl diphosphine ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, particularly in hydrogenation and cross-coupling reactions, which are essential for producing single-enantiomer pharmaceuticals and fine chemicals. This ligand is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of chiral intermediates and active ingredients.

Application

• Asymmetric Hydrogenation Catalyst Ligand: For the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical synthesis.
• Chiral Auxiliary in Cross-Coupling Reactions: Enables the formation of carbon-carbon and carbon-heteroatom bonds with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Critical for manufacturing enantiomerically pure active pharmaceutical ingredients (APIs) for CNS drugs, antivirals, and oncology treatments.
• Agrochemical Product Development: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Academic and Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.
• Fine Chemical Production: For the commercial-scale manufacture of specialty chiral compounds used in flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(Ar,Ar)-2,2'-Bis(A-N,n-Dimethylaminophenylmethyl)-(S,S)-1,1'-Bis[Di-(3,5-Dimethyl-4-Methoxyphenyl)-Phosphino]-Ferrocene
CAS No.	876608-69-4
Molecular Formula	C68H78FeN2O4P2
Molecular Weight	1105.12 g/mol
Synonyms	(S,S)-Bis(3,5-dimethyl-4-methoxyphenyl)phosphino ferrocene derivative; Josiphos SL-J009-1 type ligand; Chiral Josiphos ligand; (S,S)-2,2'-Bis[α-(N,N-dimethylamino)benzyl]-1,1'-bis(di-3,5-dimethyl-4-methoxyphenylphosphino)ferrocene; (S,S)-Bis(3,5-diMe-4-MeO-C6H2)2P-Fc-CH(Ph)NMe2; Asymmetric hydrogenation ligand 876608-69-4; SL-J009-1; DM-DTBM-SEGPHOS analog ferrocene ligand
EINECS	Contact for details

Quality Control

Our high-value chiral ligands are produced and handled under strict quality-controlled, inert environments to prevent oxidation and ensure batch-to-batch consistency. Each lot undergoes comprehensive analysis including HPLC for chiral purity and assay, 31P NMR, and 1H NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity and confirming identity. We adhere to cGMP principles for materials intended for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Identification (1H NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Assay	≥ 95.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.