Description

2-Fluorophenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. Its primary value lies in serving as a stable, air- and moisture-tolerant precursor for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl frameworks. This compound is critically needed by pharmaceutical, agrochemical, and advanced materials researchers for the efficient synthesis of fluorinated target molecules, where the fluorine atom is strategically introduced to modulate biological activity, stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating fluorinated active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Research & Development: Used in the synthesis of novel fluorinated herbicides, fungicides, and pesticides to enhance efficacy and environmental profile.
• Liquid Crystal & OLED Material Production: Employed in constructing fluorinated aromatic cores for advanced electronic displays and organic light-emitting diodes.
• Polymer & Specialty Chemical Manufacturing: Serves as a monomer or modifier for introducing fluorinated phenyl groups into polymers to alter thermal and chemical resistance.
• Academic & Contract Research: A staple reagent in university and CRO laboratories for methodology development and the synthesis of complex, fluorinated organic molecules.
• Catalyst Ligand Preparation: Can be utilized to synthesize novel bidentate or monodentate ligands for transition metal catalysis.

Basic Information

Product Name	2-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	876062-39-4
Molecular Formula	C12H16BFO2
Molecular Weight	222.07 g/mol
Synonyms	2-Fluorophenylboronic Acid Pinacol Ester; (2-Fluorophenyl)boronic Acid Pinacol Ester; 2-Fluorobenzeneboronic Acid Pinacol Ester; 4,4,5,5-Tetramethyl-2-(2-fluorophenyl)-1,3,2-dioxaborolane; Pinacol (2-Fluorophenyl)boronate; 2-FluorophenylBPin; 2-F-PhenylBPin; B-(2-Fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Fluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for prolonged use or when opening a new container to prevent hydrolysis. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.