Description

(4R,5R)-5-[3,5-Bis(Trifluoromethyl)Phenyl]-4-Methyl-1,3-Oxazolidin-2-One is a high-value, chiral oxazolidinone derivative that serves as a critical building block in advanced organic synthesis. Its primary commercial value lies in its role as a versatile chiral auxiliary or intermediate for the preparation of enantiomerically pure pharmaceuticals and agrochemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, stereochemically defined intermediates to synthesize complex target molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing new drugs targeting the central nervous system or as anti-infective agents.
• Chiral Auxiliary: Used in asymmetric synthesis to induce stereoselectivity in reactions such as aldol additions, alkylations, and Diels-Alder reactions, enabling the production of single enantiomer products.
• Agrochemical Research: Serves as a precursor in the development of novel, enantiomerically pure herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Catalyst Ligand Precursor: Can be utilized to develop novel chiral ligands for transition metal catalysis, facilitating more efficient and selective industrial chemical processes.
• Academic & R&D Laboratories: Employed in methodological research for developing new synthetic routes and studying stereochemical outcomes in organic reactions.
• Fine Chemical Synthesis: Integral for the custom synthesis of complex, high-value specialty chemicals used in electronics, materials science, and diagnostics.

Basic Information

Product Name	(4R,5R)-5-[3,5-Bis(Trifluoromethyl)Phenyl]-4-Methyl-1,3-Oxazolidin-2-One
CAS No.	875444-05-6
Molecular Formula	C₁₃H₁₁F₆NO₂
Molecular Weight	327.23 g/mol
Synonyms	(4R,5R)-4-Methyl-5-[3,5-bis(trifluoromethyl)phenyl]-2-oxazolidinone; (4R,5R)-4-Methyl-5-(3,5-bis(trifluoromethyl)phenyl)oxazolidin-2-one; (R,R)-4-Methyl-5-(3,5-bis(trifluoromethyl)phenyl)oxazolidin-2-one; Evans Auxiliary Derivative; Chiral Oxazolidinone Auxiliary; 875444-05-6; (4R-cis)-4-Methyl-5-[3,5-bis(trifluoromethyl)phenyl]-2-oxazolidinone
EINECS	Contact for details

Quality Control

Our (4R,5R)-5-[3,5-Bis(Trifluoromethyl)Phenyl]-4-Methyl-1,3-Oxazolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and purity assessment to meet exacting customer specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.