Description

Muraglitazar Acyl--D-Glucuronide is a key metabolite and reference standard of the pharmaceutical compound Muraglitazar. This high-purity chemical is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in metabolic profiling and impurity characterization.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of Muraglitazar and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, clearance mechanisms, and pharmacokinetic profile of Muraglitazar.
• Impurity Profiling and Characterization: Used to identify, quantify, and qualify process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.
• Bioanalytical Method Development: Employed as a calibrant and quality control sample in developing and validating HPLC, LC-MS, and LC-MS/MS assays.
• Regulatory Compliance and Documentation: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive characterization data for drug metabolites.
• Toxicology and Safety Assessment: Aids in the safety evaluation of drug metabolites during preclinical and clinical development stages.

Basic Information

Product Name	Muraglitazar Acyl--D-Glucuronide
CAS No.	875430-26-5
Molecular Formula	C30H30N2O11
Molecular Weight	594.57 g/mol
Synonyms	Muraglitazar Acyl Glucuronide; Muraglitazar Glucuronide; 2-[[4-[(3,5-Dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl]phenoxy]methyl]benzoic acid β-D-Glucopyranosiduronic acid; BMS-298585 Glucuronide; (2S,3S,4S,5R,6S)-6-[2-[[4-[(3,5-Dioxo-1,2-diphenylpyrazolidin-4-yl)methyl]phenoxy]methyl]benzoyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Muraglitazar Acyl--D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.