Description

3-(Difluoromethyl)-5-Hydroxybenzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a difluoromethyl and a hydroxy group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl group can enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and charge-transport materials.
• Advanced Polymer Chemistry: Acts as a monomer or modifier for creating specialty polymers with unique thermal and chemical resistance profiles.
• Chemical Research & Development: A valuable building block for exploring new fluorination chemistry and creating compound libraries for high-throughput screening.

Basic Information

Product Name	3-(Difluoromethyl)-5-Hydroxybenzonitrile
CAS No.	874974-85-3
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	5-Hydroxy-3-(difluoromethyl)benzonitrile; 3-Difluoromethyl-5-hydroxybenzonitrile; Benzonitrile, 3-(difluoromethyl)-5-hydroxy-; 874974-85-3; 5-Cyano-3-(difluoromethyl)phenol
EINECS	Contact for details

Quality Control

Our production of 3-(Difluoromethyl)-5-Hydroxybenzonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.