Description

6,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline is a fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure serves as a privileged scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily sought after by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of new drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a backbone for creating novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and organic electronic materials due to its fused ring system.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags and molecular probes to study biological systems.
• Academic & Contract Research: A valuable reagent for methodology development and exploration of new heterocyclic chemistry in university and CRO laboratories.

Basic Information

Product Name	6,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline
CAS No.	874942-09-3
Molecular Formula	C9H9F2N
Molecular Weight	169.17 g/mol
Synonyms	6,8-Difluoro-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-6,8-difluoro-isoquinoline; 6,8-Difluoro-3,4-dihydro-1H-isoquinoline; 6,8-Difluoro-1,2,3,4-tetrahydro-isoquinoline; 874942-09-3; 6,8-Difluoro-THIQ
EINECS	Contact for details

Quality Control

Our 6,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.