Description

(2R,3R,4R,5R)-5-Acetoxy-2-(Benzoyloxymethyl)-4-Fluoro-4-Methyltetrahydrofuran-3-Yl Benzoate CAS NO 874638-93-4 is a high-purity, fluorinated nucleoside derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or building block for the creation of novel antiviral and anticancer therapeutics, particularly those targeting RNA-based mechanisms. It is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analog prodrugs for antiviral and anticancer applications.
• Antiviral Drug Research: Used in the R&D of potential therapeutics targeting viruses such as hepatitis C (HCV), influenza, and other RNA viruses.
• Oncology Research: Serves as a precursor in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• ProTide Technology: A prime candidate for use in ProTide (phosphoramidate) prodrug strategies to enhance the cellular delivery and efficacy of nucleoside monophosphates.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Tool: Utilized in academic and industrial laboratories to study enzyme kinetics and mechanisms involving modified nucleosides.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Item	Details
Product Name	(2R,3R,4R,5R)-5-Acetoxy-2-(Benzoyloxymethyl)-4-Fluoro-4-Methyltetrahydrofuran-3-Yl Benzoate
CAS No.	874638-93-4
Molecular Formula	C23H21FO7
Molecular Weight	428.41 g/mol
Synonyms	4'-Fluoro-2'-methyl-uridine derivative; 2',3',5'-Tri-O-benzoyl-4'-fluoro-4'-methyluridine (common misnomer); 4'-Fluoro-4'-methyl-2',3',5'-tri-O-benzoyluridine; 1-[(2R,3R,4R,5R)-5-Acetoxy-2-(benzoyloxymethyl)-4-fluoro-4-methyl-3-tetrahydrofuranyl]-2,4(1H,3H)-pyrimidinedione 3-benzoate; Fluorinated nucleoside benzoate ester; 4'-C-Fluoro-4'-C-methyl nucleoside intermediate; PSI-6130 related intermediate; RO2433 related intermediate
EINECS	Contact for details

Quality Control

Every batch of (2R,3R,4R,5R)-5-Acetoxy-2-(Benzoyloxymethyl)-4-Fluoro-4-Methyltetrahydrofuran-3-Yl Benzoate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support regulatory filings and GMP-guided development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.