Description

3-Bromo-2-Methoxybenzonitrile is a versatile aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromine and methoxy substituents ortho to the nitrile group, makes it a valuable precursor for constructing complex heterocycles and functionalized aromatic systems. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for constructing fused ring systems and introducing specific pharmacophores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogen and nitrile functionality.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other advanced functional materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Nitrile Transformation Chemistry: The cyano group can be converted into amides, acids, tetrazoles, and other nitrogen-containing functionalities.

Basic Information

Item	Detail
Product Name	3-Bromo-2-Methoxybenzonitrile
CAS No.	874472-98-7
Molecular Formula	C8H6BrNO
Molecular Weight	212.05 g/mol
Synonyms	2-Methoxy-3-bromobenzonitrile; 3-Bromo-2-methoxybenzenecarbonitrile; 2-Cyano-6-bromoanisole; Benzonitrile, 3-bromo-2-methoxy-; 3-Bromo-o-anisonitrile
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Methoxybenzonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.