Description

4-Fluoro-3-(Methoxy(Methyl)Carbamoyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a methoxy(methyl)carbamoyl moiety, enabling further synthetic elaboration. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly for constructing complex fluorinated aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the fluorophenylboronic acid core is integral to the molecule's activity.
• Material Science Research: Employed in the creation of novel organic electronic materials, ligands for catalysts, and specialty polymers via palladium-catalyzed cross-coupling reactions.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex organic molecules for clients.

Basic Information

Product Name	4-Fluoro-3-(Methoxy(Methyl)Carbamoyl)Phenylboronic Acid
CAS No.	874290-69-4
Molecular Formula	C10H13BFNO4
Molecular Weight	241.03 g/mol
Synonyms	[4-Fluoro-3-[[methoxy(methyl)amino]carbonyl]phenyl]boronic acid; 3-Borono-4-fluoro-N-methoxy-N-methylbenzamide; 4-Fluoro-3-(N-methoxy-N-methylcarbamoyl)benzeneboronic acid; N-Methoxy-N-methyl-4-fluoro-3-boronobenzamide; B-[4-Fluoro-3-[(methoxy-methyl-carbamoyl)]phenyl]boronic acid; 874290-69-4; 4-Fluoro-3-(methoxy-methyl-carbamoyl)phenylboronic acid pinacol ester (common precursor)
EINECS	Contact for details

Quality Control

Our production of 4-Fluoro-3-(Methoxy(Methyl)Carbamoyl)Phenylboronic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure consistency and reliability. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support cGMP (current Good Manufacturing Practice) standards for applications requiring the highest level of quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.