Description

4-(Benzyloxycarbonylamino)-3-Fluorophenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected amino group with a boronic acid moiety, making it an essential reagent for Suzuki-Miyaura cross-coupling reactions. This compound is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing fluorinated biaryl structures.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for constructing carbon-carbon bonds between aromatic rings, a fundamental reaction in medicinal chemistry.
• Protease Inhibitor Research: Used in the development of protease inhibitors, where the fluorophenyl and protected amino groups are common pharmacophores.
• Agrochemical Synthesis: Employed in creating advanced fungicides and herbicides that require specific fluorinated aromatic scaffolds.
• Material Science: A building block for synthesizing novel organic electronic materials and liquid crystals.
• Peptidomimetic Chemistry: Facilitates the incorporation of fluorinated phenylalanine analogs into peptide chains for stability and bioavailability studies.

Basic Information

Product Name	4-(Benzyloxycarbonylamino)-3-Fluorophenylboronic Acid
CAS No.	874290-60-5
Molecular Formula	C14H13BFNO4
Molecular Weight	289.07 g/mol
Synonyms	3-Fluoro-4-[(phenylmethoxy)carbonylamino]benzeneboronic acid; N-Cbz-3-fluoro-4-boronophenylalanine derivative; [4-(Benzyloxycarbonylamino)-3-fluorophenyl]boronic acid; Z-3-Fluoro-4-boronophenylalanine precursor; B-[4-[[(Benzyloxy)carbonyl]amino]-3-fluorophenyl]boronic acid; 4-(N-Cbz-amino)-3-fluorobenzeneboronic acid; CAS 874290-60-5
EINECS	Contact for details

Quality Control

Our 4-(Benzyloxycarbonylamino)-3-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under an inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.