Description

5-(tert-Butylcarbamoyl)-2-Fluorobenzeneboronic Acid is a high-purity boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a protected amide moiety, enabling precise molecular construction. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly in the synthesis of complex fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel fluorinated pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic materials that require precise aromatic boronic acid incorporation.
• Chemical Biology & Probe Development: Serves as a building block for synthesizing molecular probes and diagnostic agents that target specific biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex organic molecules for clients.

Basic Information

Product Name	5-(tert-Butylcarbamoyl)-2-Fluorobenzeneboronic Acid
CAS No.	874289-51-7
Molecular Formula	C11H15BFNO3
Molecular Weight	239.06 g/mol
Synonyms	2-Fluoro-5-[(2-methylpropan-2-yl)carbamoyl]benzeneboronic Acid; (3-Fluoro-4-boronophenyl)(tert-butyl)carboxamide; 5-(tert-Butylaminocarbonyl)-2-fluorobenzeneboronic Acid; 2-Fluoro-5-(N-tert-butylcarbamoyl)phenylboronic Acid; B-[3-Fluoro-4-[(tert-butylamino)carbonyl]phenyl]boronic Acid; 874289-51-7; tert-Butyl 3-fluoro-4-boronobenzamide
EINECS	Contact for details

Quality Control

Our production of 5-(tert-Butylcarbamoyl)-2-Fluorobenzeneboronic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthesis steps. Each lot is characterized by advanced analytical techniques, including NMR, HPLC, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.