Description

2-Fluoro-5-(Piperidine-1-Carbonyl)Benzeneboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a piperidine-carbonyl moiety that introduces specific steric and electronic properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly in the creation of complex, fluorinated small molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: Used extensively in palladium-catalyzed reactions to form carbon-carbon bonds, enabling the construction of complex biaryl structures prevalent in drug discovery.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides, where the fluorine atom and amide linkage can enhance biological activity and environmental stability.
• Material Science: Serves as a monomer or functionalization agent in the synthesis of advanced organic materials, such as polymers and liquid crystals, with tailored electronic properties.
• Chemical Biology Probe Development: Utilized to create molecular probes for studying enzyme function and protein-protein interactions due to its ability to act as a transition-state analog or binding moiety.
• Library Synthesis for High-Throughput Screening: A valuable scaffold for generating diverse compound libraries to identify new lead structures in drug discovery campaigns.

Basic Information

Product Name	2-Fluoro-5-(Piperidine-1-Carbonyl)Benzeneboronic Acid
CAS No.	874289-43-7
Molecular Formula	C₁₂H₁₅BFNO₃
Molecular Weight	251.07 g/mol
Synonyms	(2-Fluoro-5-(piperidine-1-carbonyl)phenyl)boronic acid; 2-Fluoro-5-(1-piperidinecarbonyl)benzeneboronic acid; [2-Fluoro-5-(piperidine-1-carbonyl)phenyl]boronic acid; Boronic acid, B-[2-fluoro-5-(1-piperidinylcarbonyl)phenyl]-; 5-Carbamoyl-2-fluorobenzeneboronic acid piperidine derivative; 874289-43-7; 2-Fluoro-5-piperidin-1-ylcarbonylbenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(Piperidine-1-Carbonyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for cGMP and ISO-guided applications in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.