Description

2-Fluoro-4-(Piperidine-1-Carbonyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a fluorinated aromatic system and a piperidine-carbonyl moiety, enabling the construction of complex, pharmaceutically relevant scaffolds. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a versatile coupling partner to introduce the 2-fluoro-4-(piperidine-1-carbonyl)phenyl fragment into biaryl structures, a common motif in drug discovery.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that require specific fluorine-substituted aromatic systems.
• Material Science & OLED Development: Serves as a monomer or intermediate for creating advanced organic electronic materials, including charge-transport layers in OLED devices.
• Chemical Biology & Probe Synthesis: Utilized for constructing molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	2-Fluoro-4-(Piperidine-1-Carbonyl)Phenylboronic Acid
CAS No.	874289-26-6
Molecular Formula	C12H15BFNO3
Molecular Weight	251.07 g/mol
Synonyms	[2-Fluoro-4-(piperidine-1-carbonyl)phenyl]boronic acid; (2-Fluoro-4-piperidin-1-ylcarbonylphenyl)boronic acid; 2-Fluoro-4-(1-piperidinecarbonyl)benzeneboronic acid; 4-Borono-3-fluorobenzoic acid piperidide; B-[2-Fluoro-4-(1-piperidinylcarbonyl)phenyl]boronic acid; 874289-26-6; AKOS025146064; FT-0697605
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Piperidine-1-Carbonyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for research and process chemistry. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.