Description

3-Fluoro-4-(2-Hydroxyethylcarbamoyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its molecular architecture, featuring both a boronic acid group and a fluoro-substituted aromatic ring with a hydroxyethylcarbamoyl side chain, makes it a versatile intermediate for constructing complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for Suzuki-Miyaura cross-coupling reactions to create novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides by introducing the fluorinated phenylboronic acid moiety into lead structures.
• Material Science: Employed in the creation of advanced organic electronic materials and functional polymers.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of molecular probes and sensors.
• Organic Synthesis: A versatile building block for constructing complex, fluorinated biaryl compounds in academic and industrial R&D.

Basic Information

Product Name	3-Fluoro-4-(2-Hydroxyethylcarbamoyl)Phenylboronic Acid
CAS No.	874289-21-1
Molecular Formula	C9H11BFNO4
Molecular Weight	226.99 g/mol
Synonyms	3-Fluoro-4-[(2-hydroxyethyl)carbamoyl]benzeneboronic acid; [3-Fluoro-4-[(2-hydroxyethyl)carbamoyl]phenyl]boronic acid; 2-Hydroxy-N-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide (Pinacol ester precursor); B-[3-Fluoro-4-[(2-hydroxyethyl)carbamoyl]phenyl]boronic acid; 4-Borono-2-fluoro-N-(2-hydroxyethyl)benzamide
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-4-(2-Hydroxyethylcarbamoyl)Phenylboronic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.