Description

4-(Cyclohexylcarbamoyl)-3-Fluorobenzeneboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its dual functionality, serving as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions and as a key intermediate for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boron-containing partner for palladium-catalyzed C-C bond formation, enabling the construction of biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Employed as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science: A building block for organic electronic materials, such as those used in OLEDs and organic photovoltaics (OPVs).
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	4-(Cyclohexylcarbamoyl)-3-Fluorobenzeneboronic Acid
CAS No.	874289-11-9
Molecular Formula	C13H17BFNO3
Molecular Weight	265.09 g/mol
Synonyms	3-Fluoro-4-(cyclohexylaminocarbonyl)benzeneboronic Acid; [3-Fluoro-4-(N-cyclohexylcarbamoyl)phenyl]boronic Acid; 4-(Cyclohexylcarbamoyl)-3-fluorophenylboronic Acid; B-[4-(Cyclohexylaminocarbonyl)-3-fluorophenyl]boronic Acid; 3-Fluoro-N-cyclohexyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (Pinacol Ester Precursor); 874289-11-9; FC6H3(CONHC6H11)B(OH)2
EINECS	Contact for details

Quality Control

Our 4-(Cyclohexylcarbamoyl)-3-Fluorobenzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.