Description

3-Fluoro-4-(Piperidine-1-Carbonyl)Benzeneboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling reactions with a piperidine-carbonyl moiety that introduces specific steric and electronic properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders, due to the piperidine scaffold.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorine and boronic acid groups are essential for bioactivity.
• Material Science Research: Employed in the development of organic electronic materials and metal-organic frameworks (MOFs) where precise molecular structure is critical.
• Cross-Coupling Reactions: Serves as a versatile coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to form biaryl and heterobiaryl bonds.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	3-Fluoro-4-(Piperidine-1-Carbonyl)Benzeneboronic Acid
CAS No.	874289-10-8
Molecular Formula	C₁₂H₁₅BFNO₃
Molecular Weight	251.06 g/mol
Synonyms	[3-Fluoro-4-(piperidine-1-carbonyl)phenyl]boronic acid; (3-Fluoro-4-(piperidine-1-carbonyl)phenyl)boronic acid; B-[3-Fluoro-4-(1-piperidinylcarbonyl)phenyl]boronic acid; 3-Fluoro-4-piperidin-1-ylcarbonylbenzeneboronic acid; 4-Borono-2-fluoro-N-piperidin-1-ylbenzamide; 874289-10-8; AKOS006361889
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-4-(Piperidine-1-Carbonyl)Benzeneboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support cGMP and ISO 9001 standards for pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.