Description

4-Ethoxycarbonyl-3-Fluorophenylboronic Acid is a high-value organoboron building block, specifically a functionalized phenylboronic acid derivative. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern synthetic chemistry for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and advanced materials where the ethoxycarbonyl and fluorine substituents offer critical synthetic handles and modulate biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, including kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Research: Used to construct novel fluorinated scaffolds for next-generation herbicides, fungicides, and pesticides, leveraging the metabolic stability imparted by fluorine.
• Material Science: Serves as a precursor for creating functionalized organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorophore-labeled molecules or activity-based probes for imaging and diagnostic applications.
• Academic & Contract Research: A vital reagent for methodological development in cross-coupling chemistry and the exploration of new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	4-Ethoxycarbonyl-3-Fluorophenylboronic Acid
CAS No.	874288-38-7
Molecular Formula	C9H10BFO4
Molecular Weight	211.99 g/mol
Synonyms	(4-Ethoxycarbonyl-3-fluorophenyl)boronic acid; 3-Fluoro-4-(ethoxycarbonyl)benzeneboronic acid; 4-Carbethoxy-3-fluorophenylboronic acid; Ethyl 4-borono-2-fluorobenzoate; 2-Fluoro-4-boronobenzoic acid ethyl ester; B-(4-Ethoxycarbonyl-3-fluorophenyl)boronic acid; 874288-38-7
EINECS	Contact for details

Quality Control

Our 4-Ethoxycarbonyl-3-Fluorophenylboronic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR (¹H, ¹¹B, ¹³C, ¹⁹F) for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic (moisture-sensitive) nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.