Description

R-n-Methyl-n-[(1S)-1-Phenylethyl]-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine is a sophisticated chiral organophosphorus compound, specifically a P-stereogenic phosphine ligand, designed for high-performance asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and catalytic activity in critical bond-forming reactions, offering a significant advantage for the synthesis of complex chiral molecules. This advanced ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing new active ingredients and high-value intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral alcohols and amines in pharmaceutical synthesis.
• Asymmetric Cross-Coupling Reactions: Employed in Buchwald-Hartwig amination and Suzuki-Miyaura coupling to construct C-N and C-C bonds with high stereoselectivity.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and oncology.
• Agrochemical Development: Used in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is often enantiomer-specific.
• Fine Chemical and Fragrance Manufacturing: Facilitates the creation of enantiomerically pure flavors, fragrances, and specialty chemicals.
• Academic and Process R&D: Serves as a valuable tool for methodology development and scaling up asymmetric catalytic processes in research laboratories.

Basic Information

Product Name	R-n-Methyl-n-[(1S)-1-Phenylethyl]-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine
CAS No.	874221-90-6
Molecular Formula	C31H26NO2P
Molecular Weight	475.51 g/mol
Synonyms	(R)-Methyl((S)-1-phenylethyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; (R)-Methyl((S)-1-phenylethyl)-4H-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; (R)-Methyl((S)-1-phenylethyl)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; (R)-Methyl((S)-1-phenylethyl)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; (R)-Methyl((S)-1-phenylethyl)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; (R)-Methyl((S)-1-phenylethyl)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; (R)-Methyl((S)-1-phenylethyl)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine; (R)-Methyl((S)-1-phenylethyl)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine
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Quality Control

Our R-n-Methyl-n-[(1S)-1-Phenylethyl]-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee reproducible performance in your catalytic applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized and hygroscopic, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.