Description

3-(Boc-Amino)-4-Fluorophenylboronic Acid is a high-purity, advanced pharmaceutical intermediate and a versatile building block in modern synthetic chemistry. This compound is critically important for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl halides and boronic acids, essential for creating complex molecular architectures in drug discovery.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a precursor for the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of probes and linkers for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific fluorinated and protected aniline derivatives.

Basic Information

Product Name	3-(Boc-Amino)-4-Fluorophenylboronic Acid
CAS No.	874219-58-6
Molecular Formula	C11H15BFNO4
Molecular Weight	255.05 g/mol
Synonyms	tert-Butyl N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate; 4-Fluoro-3-[(tert-butoxycarbonyl)amino]benzeneboronic acid; 3-(Boc-amino)-4-fluorobenzeneboronic acid; 3-((tert-Butoxycarbonyl)amino)-4-fluorophenylboronic acid; BOC-4-Fluoro-3-aminophenylboronic acid; 4-Fluoro-3-aminophenylboronic acid BOC-protected; 874219-58-6; BOC-Protected 3-Amino-4-fluorophenylboronic Acid
EINECS	Contact for details

Quality Control

Our 3-(Boc-Amino)-4-Fluorophenylboronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.