Description

Mpeg4-Nhs CAS NO 874208-94-3 is a heterobifunctional polyethylene glycol (PEG) derivative featuring an active NHS ester and a methoxy end group. This compound is a critical reagent for creating stable, biocompatible conjugates, enabling the precise attachment of biomolecules to surfaces, nanoparticles, or other proteins. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced material science for applications such as drug delivery system optimization and diagnostic assay development.

Application

• Bioconjugation and Crosslinking: Used to covalently link amines on proteins, peptides, or antibodies to other functional groups or surfaces.
• PEGylation of Therapeutics: A key reagent for attaching PEG chains to drugs or proteins to enhance solubility, reduce immunogenicity, and prolong circulation time in the body.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, or biosensor surfaces with PEG spacers to improve biocompatibility and provide a handle for further coupling.
• Diagnostic Reagent Synthesis: Facilitates the creation of stable enzyme-antibody or hapten-carrier protein conjugates used in ELISA and other immunoassays.
• Hydrogel and Biomaterial Fabrication: Serves as a crosslinker or modifier in the synthesis of PEG-based hydrogels for tissue engineering and controlled release applications.
• ADC (Antibody-Drug Conjugate) Development: Acts as a linker component to connect cytotoxic payloads to monoclonal antibodies.

Basic Information

Product Name	Mpeg4-Nhs
CAS No.	874208-94-3
Molecular Formula	C23H41NO11
Molecular Weight	507.58 g/mol
Synonyms	mPEG4-NHS ester; α-Methoxy-ω-N-succinimidyl PEG4; Methoxy-PEG4-NHS ester; mPEG4-NHS; NHS-PEG4-OMe; 4-Arm PEG-NHS ester (Note: verify specific architecture); Succinimidyl ester of methoxy tetraethylene glycol; N-(Methoxy poly(ethylene glycol)4)succinimide
EINECS	Contact for details

Quality Control

Our Mpeg4-Nhs is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the NHS ester group is susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (NHS Ester)	≥ 90%
Solubility	Soluble in DMSO, DMF, acetonitrile, and dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.